The SENTERRA II Confocal Raman Microscope from Bruker is an advanced, automation-driven Raman platform designed for reliable, high-throughput analysis in research laboratories and industrial settings. Engineered for continuous operation, it combines research-grade spectral performance with intuitive workflows, allowing users to obtain precise, reproducible Raman data with minimal manual intervention. SENTERRA II supports demanding applications such as material identification, failure investigation, quality control, and advanced scientific research. Nexus Analyticals is a trusted distributor and service provider for SENTERRA II in India, offering comprehensive local support.
Raman Microscopes
SENTERRA II Raman Microscope
What you need to know about SENTERRA II Raman Microscope?
Intelligent Automation for Effortless Raman Analysis
SENTERRA II redefines ease of use in Raman microscopy through extensive system automation. Critical operational steps—including laser selection, optical alignment, focus optimisation, spectral acquisition, and Raman mapping—are handled automatically. This reduces dependency on operator expertise, improves measurement consistency, and significantly increases analytical throughput across routine and complex workflows.
Key Benefits
- Factory-aligned and calibrated system ensures immediate operational readiness.
- Extensive automation reduces setup time and limits operator-induced variability.
- Compact, rugged design suitable for laboratory and production environments
- Consistent performance across long analytical sessions and high sample volumes
Designed for Reproducibility, Accuracy, and Safety
SENTERRA II is built around three fundamental principles: reliable reproducibility, precise spectral accuracy, and secure operation. These attributes make it an ideal solution for academic research, industrial QA/QC, and routine analytical laboratories.
- Automated control of lasers, gratings, and filters ensures consistent measurement conditions.
- Integrated system checks and qualification routines support long-term stability.
- Enclosed Class 1 laser safety housing enables safe operation for students and non-specialist users.
SureCal™ Technology – Continuous Calibration Assurance
Traditional Raman systems can experience calibration drift due to temperature changes or mechanical movement. SENTERRA II eliminates this risk using SureCal™, which continuously maintains calibration throughout operation.
- No manual recalibration steps required
- Stable sub-wavenumber accuracy during extended or high-throughput measurements
- Ideal for chemometric analysis, Raman mapping, and material identification
- Consistent spectral quality under varying environmental and workload conditions
Life Science Compatibility with Inverted Microscope Configuration
For biomedical and pharmaceutical research, SENTERRA II is available in an inverted microscope configuration while maintaining full confocal Raman performance. This design improves access to sensitive samples and supports advanced life-science workflows.
- Live-cell and tissue analysis with unobstructed sample access
- In-vitro pharmaceutical and biomedical investigations
- In-situ Raman studies requiring flexible sample handling
End-to-End Support in India
Nexus Analyticals delivers complete SENTERRA II support across India, including instrument consultation, system demonstrations, installation, operator training, and ongoing maintenance. Whether used in materials science, pharmaceuticals, research institutions, or industrial QA/QC environments, SENTERRA II is backed by responsive local expertise to ensure sustained performance.
Performance, Usability, and Compliance
Automation & User Experience
- Fully automated hardware architecture for streamlined operation
- One-click laser switching across up to four integrated excitation sources.
- Rapid creation of custom workflows with intuitive software tools
- Clean, logical interface supporting both new and experienced users
Spectral Performance & Technology
- Research-level spectral sensitivity and resolution
- SureCal™ automatic calibration for continuous wavenumber accuracy
- Fast 3D Raman imaging using a precision motorised XYZ stage
- Excellent spatial resolution with outstanding spectral stability
Data Handling & System Integration
- Advanced spectral analysis and compound identification capabilities
- Compatibility with FT-Raman to minimise fluorescence effects
- Seamless connectivity with Bruker FT-IR systems for complementary analysis
Maintenance & Regulatory Readiness
- Built-in self-diagnostics with automated OQ/PQ routines
- Low-maintenance system architecture for long-term reliability
- Designed to meet GMP requirements and 21 CFR Part 11 compliance
It's the Swiss-Knife of Raman Microscopes
SENTERRA II Raman Microscope Features:
- Confocal optical architecture delivering high spatial resolution and depth-resolved analysis
- Automated switching of lasers, filters, and gratings for uninterrupted multi-wavelength operation
- Motorised XYZ stage enabling rapid, high-resolution Raman imaging and 3D mapping
- Stable, high-performance spectral output with minimal user adjustments
- Support for multiple excitation wavelengths to address diverse sample types
- Powerful, user-friendly software designed for both routine users and advanced researchers
Applications of SENTERRA II Raman Microscope
- Failure Analysis: Identification of micro-defects and contamination
- Quality Control: Rapid material verification in manufacturing workflows
- Pharmaceuticals: Polymorph analysis, coating uniformity, and impurity detection
- Semiconductors & Electronics: Stress, crystallinity, and layer analysis
- Scientific Research: Advanced molecular and materials investigations
- Material Science: Structural and crystallinity characterisation
- Polymers & Plastics: Additive detection and integrity assessment
- Environmental Studies: Microplastic and pollutant identification
- Forensics: Trace analysis and drug identification
TECHNICAL SUPPORT FOR SENTERRA II RAMAN MICROSCOPE
We provide comprehensive technical support, application assistance, and maintenance services for the MPA III FT-NIR Spectrometer, ensuring stable operation, accurate analytical results, and long-term instrument reliability. Our support covers system installation, method development, calibration, troubleshooting, and software assistance across pharmaceutical, food, chemical, polymer, and agricultural applications. As an Authorized Distributor of Bruker Optics GmbH & Co. KG in India, we deliver specialized service and application support aligned with regulatory, quality, and operational requirements of modern analytical laboratories.
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Instrument setup & configuration
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System installation, module and probe selection, optical alignment, detector and source optimization, and performance verification.
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Method development
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Selection of measurement mode, spectral range, resolution, scan parameters, sampling techniques, and development of robust NIR methods.
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Calibration & validation
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Wavelength and photometric calibration, performance qualification (IQ/OQ/PQ), reference material verification, and chemometric model validation.
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Data acquisition issues
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Low signal intensity, noisy spectra, baseline instability, sampling inconsistencies, probe contamination, and repeatability concerns.
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Data interpretation
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Spectral evaluation, identification of chemical and physical variations, multivariate analysis (PCA, PLS), and correlation with reference methods.
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Troubleshooting errors
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Optical path issues, fiber or probe damage, detector or source faults, environmental effects, model prediction errors, and software warnings.
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Maintenance & best practices
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Routine system checks, cleaning of accessories, lamp monitoring, reference scans, preventive maintenance, and contamination control.
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Software help
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OPUS software support, chemometric model development, calibration transfer, library management, validation workflows, and reporting.
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